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T1  - Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression 
SN  -  /  
UR  - http://hdl.handle.net/10138/236615 
T3  -  
A1  - Panahi, Mahmod; Mesri, Naeimeh Yousefi; Samuelsson, Eva-Britt; Coupland, Kirsten G.; Forsell, Charlotte; Graff, Caroline; Tikka, Saara; Winblad, Bengt; Viitanen, Matti; Karlström, Helena; Sundström, Erik; Behbahani, Homira 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a familial fatal progressive degenerative disorder. One of the pathological hallmarks of CADASIL is a dramatic reduction of vascular smooth muscle cells (VSMCs) in cerebral arteries. Using VSMCs from the vasculature of the human umbilical cord, placenta and cerebrum of CADASIL patients, we found that CADASIL VSMCs had a lower proliferation rate compared to control VSMCs. Exposure of control VS... 
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KW  - CADASIL; endothelial cells; NOTCH3; Transforming growth factor-beta; vascular smooth muscle cells; GROWTH-FACTOR-BETA; AUTOSOMAL-DOMINANT ARTERIOPATHY; SUBCORTICAL INFARCTS; WHITE-MATTER; ENDOTHELIAL-CELLS; BRAIN INFARCTS; MUTATIONS; LEUKOENCEPHALOPATHY; SPECTRUM; ENDOGLIN; 3111 Biomedicine 
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