TY - T1 - Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation SN - / UR - http://hdl.handle.net/10138/165261 T3 - A1 - Tailford, Louise E.; Owen, C. David; Walshaw, John; Crost, Emmanuelle H.; Hardy-Goddard, Jemma; Le Gall, Gwenaelle; de Vos, Willem M.; Taylor, Garry L.; Juge, Nathalie A2 - PB - Y1 - 2015 LA - eng AB - The gastrointestinal mucus layer is colonized by a dense community of microbes catabolizing dietary and host carbohydrates during their expansion in the gut. Alterations in mucosal carbohydrate availability impact on the composition of microbial species. Ruminococcus gnavus is a commensal anaerobe present in the gastrointestinal tract of > 90% of humans and overrepresented in inflammatory bowel diseases (IBD). Using a combination of genomics, enzymology and crystallography, we show that the muci... VO - IS - SP - OP - KW - INFLAMMATORY BOWEL DISEASES; SIALIC-ACID; STREPTOCOCCUS-PNEUMONIAE; ENTERIC PATHOGENS; CRYSTAL-STRUCTURE; MUCUS LAYERS; MUCIN; BACTERIA; SPECIFICITY; METABOLISM; 3111 Biomedicine N1 - PP - ER -