TY  -  
T1  - Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms : Possible Implications for New Antifibrotic Therapies 
SN  -  /  
UR  - http://hdl.handle.net/10138/325633 
T3  -  
A1  - Karhu, S. Tuuli; Ruskoaho, Heikki; Talman, Virpi 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Cardiac fibrosis is characterized by accumulation and activation of fibroblasts and excessive production of extracellular matrix, which results in myocardial stiffening and eventually leads to heart failure. Although previous work suggests that protein kinase C (PKC) isoforms play a role in cardiac fibrosis and remodeling, the results are conflicting. Moreover, the potential of targeting PKC with pharmacological tools to inhibit pathologic fibrosis has not been fully evaluated. Here we investiga... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 317 Pharmacy; PKC-ALPHA; PHARMACOLOGICAL INHIBITION; MYOCARDIAL-INFARCTION; HEART-FAILURE; DOMAIN; EXPRESSION; FIBROSIS; EPSILON; DIFFERENTIATION; DYSFUNCTION 
N1  -   
PP  -  
ER  -