TY  -  
T1  - Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi 
SN  -  /  
UR  - http://hdl.handle.net/10138/319661 
T3  -  
A1  - Hong, Seon Pyo; Yang, Myung Jin; Cho, Hyunsoo; Park, Intae; Bae, Hosung; Choe, Kibaek; Suh, Sang Heon; Adams, Ralf H.; Alitalo, Kari; Lim, Daesik; Koh, Gou Young 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of heterogeneity within the villi stromal compartment and how IntSCs regulate the structure and function of specialized intestinal lymphatic capillary called lacteal remain elusive. Here we show that selective hyperactivation or depletion of YAP/TAZ in PDGFR beta(+) IntSCs leads to lacteal sprouting or regression with junctional disintegration and impa... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - HIPPO PATHWAY; CARDIOMYOCYTE PROLIFERATION; LYMPHATIC VASCULATURE; YAP; CELLS; REGENERATION; MECHANISMS; GROWTH; 3111 Biomedicine 
N1  -   
PP  -  
ER  -