TY  -  
T1  - Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster 
SN  -  /  
UR  - http://hdl.handle.net/10138/228648 
T3  -  
A1  - Walkowicz, Lucyna; Kijak, Ewelina; Krzeptowski, Wojciech; Gorska-Andrzejak, Jolanta; Stratoulias, Vassilis; Woznicka, Olga; Chwastek, Elzbieta; Heino, Tapio I.; Pyza, Elzbieta M. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor(DmMANF) is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF), which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especially high levels of DmMANF in the visual system of Drosophil a, particularly in the first optic neuropil (lamina). In the lamina, DmMANF was found in glial cells (surface and epithelial glia), photorece... 
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KW  - MANF; CDNF; neurotrophic factor; visual system; neuroprotection; neurodegeneration; NEUROTROPHIC FACTOR; VISUAL-SYSTEM; PARKINSONS-DISEASE; PHOTORECEPTOR TERMINALS; CAPITATE PROJECTIONS; DOPAMINERGIC-NEURONS; BRAIN DEGENERATION; CDNF/MANF FAMILY; OPTIC NEUROPIL; CDNF PROTECTS; 3112 Neurosciences 
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ER  -