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T1  - Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer 
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UR  - http://hdl.handle.net/10138/304567 
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A1  - Malyutina, Alina; Majumder, Muntasir Mamun; Wang, Wenyu; Pessia, Alberto; Heckman, Caroline A.; Tang, Jing 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - High-throughput drug screening has facilitated the discovery of drug combinations in cancer. Many existing studies adopted a full matrix design, aiming for the characterization of drug pair effects for cancer cells. However, the full matrix design may be suboptimal as it requires a drug pair to be combined at multiple concentrations in a full factorial manner. Furthermore, many of the computational tools assess only the synergy but not the sensitivity of drug combinations, which might lead to fa... 
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KW  - ANTICANCER; CELL; IDENTIFY; MODELS; SCREEN; THERAPY; 1182 Biochemistry, cell and molecular biology; 113 Computer and information sciences; 3122 Cancers 
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