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T1  - Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer 
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UR  - http://hdl.handle.net/10138/309442 
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A1  - Facciotto, Chiara; Casado, Julia; Turunen, Laura; Leivonen, Suvi-Katri; Tumiati, Manuela; Rantanen, Ville; Kauppi, Liisa; Lehtonen, Rainer; Leppä, Sirpa; Wennerberg, Krister; Hautaniemi, Sampsa 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Background The epigenome plays a key role in cancer heterogeneity and drug resistance. Hence, a number of epigenetic inhibitors have been developed and tested in cancers. The major focus of most studies so far has been on the cytotoxic effect of these compounds, and only few have investigated the ability to revert the resistant phenotype in cancer cells. Hence, there is a need for a systematic methodology to unravel the mechanisms behind epigenetic sensitization. Results We have developed a high... 
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KW  - 1184 Genetics, developmental biology, physiology; Epigenetic; Epigenetic reprogramming; Epigenetic inhibitors; High-throughput drug screening; 3122 Cancers; Diffuse large B-cell lymphoma 
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ER  -