TY  -  
T1  - Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors 
SN  -  /  
UR  - http://hdl.handle.net/10138/248406 
T3  -  
A1  - Kolberg, Matthias; Bruun, Jarle; Murumagi, Astrid; Mpindi, John P.; Bergsland, Christian H.; Holand, Maren; Eilertsen, Ina A.; Danielsen, Stine A.; Kallioniemi, Olli; Lothe, Ragnhild A. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Patients with malignant peripheral nerve sheath tumor (MPNST), a rare soft tissue cancer associated with loss of the tumor suppressor neurofibromin (NF1), have poor prognosis and typically respond poorly to adjuvant therapy. We evaluated the effect of 299 clinical and investigational compounds on seven MPNST cell lines, two primary cultures of human Schwann cells, and five normal bone marrow aspirates, to identify potent drugs for MPNST treatment with few side effects. Top hits included Polo-lik... 
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IS  -  
SP  -  
OP  -  
KW  - drug screen; MPNST; pharmacology; Schwann cell; NEUROFIBROMATOSIS TYPE-1 PATIENTS; SCHWANNOMA CELL-LINE; SOFT-TISSUE SARCOMA; PHASE-II; CANCER-THERAPY; IN-VITRO; KINASE 1; GENE; GROWTH; RAS; 3122 Cancers 
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PP  -  
ER  -