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T1  - Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool 
SN  -  /  
UR  - http://hdl.handle.net/10138/228754 
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A1  - Zega, Ksenija; Jovanovic, Vukasin M.; Vitic, Zagorka; Niedzielska, Magdalena; Knaapi, Laura; Jukic, Marin M.; Partanen, Juha; Friedel, Roland F.; Lang, Roland; Brodski, Claude 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Hydrocephalus can occur in children alone or in combination with other neurodevelopmental disorders that are often associated with brain overgrowth. Despite the severity of these disorders, the molecular and cellular mechanisms underlying these pathologies and their comorbidity are poorly understood. Here, we studied the consequences of genetically inactivating in mice dual-specificity phosphatase 16 (Dusp16), which is known to negatively regulate mitogen-activated protein kinases (MAPKs) and wh... 
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KW  - DUSP16; hydrocephalus; brain overgrowth; megalencephaly; macrocephaly; neurogenesis; neural differentiation; neuronal progenitors; PROTEIN-KINASE PHOSPHATASE; SUBCOMMISSURAL ORGAN; STIMULATES PROLIFERATION; INFANTILE HYDROCEPHALUS; NEONATAL HYDROCEPHALUS; ADULT HIPPOCAMPUS; NERVOUS-SYSTEM; CELLS LEADS; MOUSE MODEL; STEM-CELLS; 3112 Neurosciences; 3124 Neurology and psychiatry 
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ER  -