TY  -  
T1  - Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation 
SN  -  /  
UR  - http://hdl.handle.net/10138/269348 
T3  -  
A1  - Leino, Sakari; Kohtala, Samuel; Rantamäki, Tomi; Koski, Sini K; Rannanpää, Saara; Salminen, Outi 
A2  -  
PB  - BioMed Central 
Y1  - 2018 
LA  - eng 
AB  - Abstract
              
                Background
                The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic denervation. While the mechanisms of LID remain incompletely understood, elevated corticostriatal levels of the brain-derived neurotrophic factor (BDNF) have been suggested to play a role. Here, fe... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Parkinson’s disease; Levodopa-induced dyskinesia; BDNF; Nicotine; Alpha7 nicotinic receptors 
N1  -   
PP  -  
ER  -