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T1  - Early epithelial signaling center governs tooth budding morphogenesis 
SN  -  /  
UR  - http://hdl.handle.net/10138/174149 
T3  -  
A1  - Ahtiainen, Laura; Uski, Isa; Thesleff, Irma; Mikkola, Marja L. 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells emerges in the early tooth primordium and identify these cells as a signaling center. Con... 
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KW  - ECTODERMAL APPENDAGE MORPHOGENESIS; HAIR FOLLICLE DEVELOPMENT; NF-KAPPA-B; MAMMALIAN TOOTH; ENAMEL KNOT; INCISOR DEVELOPMENT; DENTAL MESENCHYME; SHH EXPRESSION; TABBY MOUSE; ECTODYSPLASIN; 1182 Biochemistry, cell and molecular biology 
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ER  -