TY - T1 - Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia SN - / UR - URN:ISBN:978-951-51-6673-9; http://hdl.handle.net/10138/320993 T3 - A1 - Mustonen, Neea A2 - PB - Helsingin yliopisto Y1 - 2020 LA - en AB - Background: The incidence of immune-mediated diseases, such as type 1 diabetes (T1D), celiac disease (CD), and allergic diseases, has been increasing since the 1950s. This trend has been particularly conspicuous in affluent Westernized countries. Etiologies behind these diseases are still poorly understood, but socioeconomic circumstances and environmental factors may play a crucial role in their pathomechanisms. The hygiene hypothesis aims to explain the rising trend in immune-mediated diseases... VO - IS - SP - OP - KW - lääketieteellinen tiedekunta N1 - PP - ER -