TY  -  
T1  - Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria 
SN  -  /  
UR  - http://hdl.handle.net/10138/231582 
T3  -  
A1  - Hilander, Taru; Zhou, Xiao-Long; Konovalova, Svetlana; Zhang, Fu-Ping; Euro, Liliya; Shilov, Dmitri; Poutanen, Matti; Chihade, Joseph; Wang, En-Duo; Tyynismaa, Henna 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs mischarged with noncognate amino acids. Mouse models of editing-defective cytoplasmic alanyl-tRNA synthetase (AlaRS) have previously demonstrated the importance of proofreading for cytoplasmic protein synthesis, with embryonic lethal and progressive neurodegeneration pheno... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 3111 Biomedicine; QUALITY-CONTROL; HUMAN-DISEASE; SYNTHETASE MUTATIONS; PROTEIN-SYNTHESIS; AMINOACYLATION; DEFECTS; MISTRANSLATION; RECOGNITION; POLYMERASE; PROTEASES 
N1  -   
PP  -  
ER  -