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T1  - Effect of Donor Simvastatin Treatment on Gene Expression Profiles in Human Cardiac Allografts during Ischemia-Reperfusion Injury 
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UR  - http://hdl.handle.net/10138/313827 
T3  -  
A1  - Krebs, R.; Kankainen, M.; Holmström, E.; Dhaygude, K.; Lukac, J.; Ojala, T.; Mattila, P.; Nykänen, A.; Lemström, K. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Purpose Numerous studies have shown that statin therapy initiated early after heart transplantation has beneficial effects on the development of cardiac allograft vasculopathy. Recently, we were able to show in a randomized clinical trial that simvastatin treatment of brain-dead donors conditions the heart transplant to withstand ischemia-reperfusion injury and to reduce the need for rejection treatments early after transplantation. In this study, we analyzed myocardial gene expression profiles ... 
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