TY  -  
T1  - Effect of Double Substitution in Cationic Chitosan Derivatives on DNA Transfection Efficiency 
SN  -  /  
UR  - http://hdl.handle.net/10138/317893 
T3  -  
A1  - Badazhkova, Veronika D.; Raik, Sergei; Polyakov, Dmitry S.; Poshina, Daria N.; Skorik, Yury A. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Recently, much effort has been expended on the development of non-viral gene delivery systems based on polyplexes of nucleic acids with various cationic polymers. Natural polysaccharide derivatives are promising carriers due to their low toxicity. In this work, chitosan was chemically modified by a reaction with 4-formyl-n,n,n-trimethylanilinium iodide and pyridoxal hydrochloride and subsequent reduction of the imine bond with NaBH4. This reaction yielded three novel derivatives, n-[4-(n',n',n'-... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - chitosan; polyplex; cell transfection; gene delivery; GENE-THERAPY; PROTON-SPONGE; IN-VITRO; DELIVERY; POLYPLEXES; VECTORS; DESTABILIZATION; NANOPARTICLES; MECHANISM; 1182 Biochemistry, cell and molecular biology; 317 Pharmacy 
N1  -   
PP  -  
ER  -