TY  -  
T1  - Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels : A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study 
SN  -  /  
UR  - http://hdl.handle.net/10138/170069 
T3  -  
A1  - Nowak, Christoph; Salihovic, Samira; Ganna, Andrea; Brandmaier, Stefan; Tukiainen, Taru; Broeckling, Corey D.; Magnusson, Patrik K.; Prenni, Jessica E.; Wang-Sattler, Rui; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Giedraitis, Vilmantas; Arnlov, Johan; Berne, Christian; Gieger, Christian; Ripatti, Samuli; Lind, Lars; Pedersen, Nancy L.; Sundstrom, Johan; Ingelsson, Erik; Fall, Tove 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to disentangle. We combined untargeted plasma metabolomics by liquid chromatography/mass spectrometry in three non-diabetic cohorts with Mendelian Randomization (MR) analysis to obtain new insights into early metabolic alterations in IR and impaired insulin secretion. In up to 910... 
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IS  -  
SP  -  
OP  -  
KW  - STEAROYL-COA DESATURASE; HOMEOSTASIS MODEL ASSESSMENT; GENOME-WIDE ASSOCIATION; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; GENE-EXPRESSION; OBESE MICE; RAT-LIVER; DYSFUNCTION; HEART; 3142 Public health care science, environmental and occupational health; 3111 Biomedicine 
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ER  -