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T1  - Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting 
SN  -  /  
UR  - http://hdl.handle.net/10138/342088 
T3  -  
A1  - Nurmio, Mirja; Asadi-Azarbaijani, Babak; Hou, Mi; Kiviö, Ronja; Toppari, Jorma; Tinkanen, Helena; Laine, Tiina; Oskam, Irma C.; Jahnukainen, Kirsi 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Simple Summary Cryopreservation of ovarian tissue is a promising technique for fertility preservation in cancer patients at increased risk for subfertility. The International Guideline Harmonization Group recommends ovarian tissue cryopreservation for children and young adults before therapy with cumulative doses of alkylating agent at or above 6000-8000 mg/m(2). A therapy that poses a high risk of subfertility is rarely the first-line therapy and many of the patients have already undergone seve... 
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KW  - fertility preservation; children and young adults; alkylating agents; xenografting; ovarian follicles; FERTILITY PRESERVATION; TRANSPLANTATION; LEUKEMIA; CANCER; CHILDHOOD; XENOTRANSPLANTATION; ACTIVATION; SELECTION; AUTOGRAFT; PUBERTY; 3122 Cancers 
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