TY  -  
T1  - Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration 
SN  -  /  
UR  - http://hdl.handle.net/10138/157020 
T3  -  
A1  - Maejima, Ryuhei; Iijima, Katsunori; Kaihovaara, Pertti; Hatta, Waku; Koike, Tomoyuki; Imatani, Akira; Shimosegawa, Tooru; Salaspuro, Mikko 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30-50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for upper aerodigestive tract cancers, i.e., head and neck cancer and esophageal cancer. However, there is only a limited evidence for stomach cancer. In this study we demonstrated for the first time that ALDH2 defici... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - SQUAMOUS-CELL CARCINOMA; HELICOBACTER-PYLORI INFECTION; CHRONIC ATROPHIC GASTRITIS; UPPER AERODIGESTIVE TRACT; ALDEHYDE DEHYDROGENASE 2; ETHANOL-METABOLISM; STOMACH-CANCER; ALDH2-DEFICIENT SUBJECTS; MICROBIAL-PRODUCTION; RISK; 3121 General medicine, internal medicine and other clinical medicine 
N1  -   
PP  -  
ER  -