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T1  - Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats 
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UR  - http://hdl.handle.net/10138/333306 
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A1  - Pohjanvirta, Raimo; Karppinen, Ira; Galban-Velazquez, Suylen; Esteban, Javier; Håkansson, Helen; Sankari, Satu; Linden, Jere 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - The physiological functions of the aryl hydrocarbon receptor (AHR) are only beginning to unfold. Studies in wildtype and AHR knockout (AHRKO) mice have recently disclosed that AHR activity is required for obesity and steatohepatitis to develop when mice are fed with a high-fat diet (HFD). In addition, a line of AHRKO mouse has been reported to accumulate retinoids in the liver. Whether these are universal manifestations across species related to AHR activity level is not known yet. Therefore, we... 
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KW  - Aryl hydrocarbon receptor; Genetically modified organisms; High-fat diet; Diet-induced obesity; Energy balance; Retinoids; INDUCED OBESITY; REGIONAL DIFFERENCES; METABOLIC-DISORDERS; INSULIN-RESISTANCE; DIOXIN RECEPTOR; WISTAR RATS; AHR; MICE; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; THERMOGENESIS; 1182 Biochemistry, cell and molecular biology; 416 Food Science 
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