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T1  - Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes 
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UR  - http://hdl.handle.net/10138/161076 
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A1  - Kuusela, Jukka; Kujala, Ville J.; Kiviaho, Anna; Ojala, Marisa; Swan, Heikki; Kontula, Kimmo; Aalto-Setala, Katriina 
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Y1  - 2016 
LA  - eng 
AB  - Human induced pluripotent stem cells (hiPSC) have enabled a major step forward in pathophysiologic studies of inherited diseases and may also prove to be valuable in in vitro drug testing. Long QT syndrome (LQTS), characterized by prolonged cardiac repolarization and risk of sudden death, may be inherited or result from adverse drug effects. Using a microelectrode array platform, we investigated the effects of six different drugs on the electrophysiological characteristics of human embryonic ste... 
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KW  - Induced pluripotent stem cell; Patient-specific; Long QT syndrome; Cardiomyocytes; Multielectrode array; Cardioactive drug; Arrhythmia; TORSADES-DE-POINTES; POTASSIUM CHANNEL; FOUNDER MUTATIONS; HUMAN HEART; KVLQT1; REPOLARIZATION; DIFFERENTIATION; PROLONGATION; ARRHYTHMIAS; PREVALENCE; 3121 General medicine, internal medicine and other clinical medicine 
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