TY  -  
T1  - Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine 
SN  -  /  
UR  - http://hdl.handle.net/10138/306500 
T3  -  
A1  - Tapio, H. A.; Raekallio, M. R.; Mykkänen, A. K.; Al-Ramahi, D.; Scheinin, M.; Hautajarvi, H. J.; Männikkö, S.; Vainio, O. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - A constant rate infusion (CRI) of medetomidine is used to balance equine inhalation anesthesia, but its cardiovascular side effects are a concern. This experimental crossover study aimed to evaluate the effects of vatinoxan (a peripheral a2-adrenoceptor antagonist) on cardiorespiratory and gastrointestinal function in anesthetized healthy horses. Six horses received medetomidine hydrochloride 7 mu g/kg IV alone (MED) or with vatinoxan hydrochloride 140 mu g/kg IV (MED + V). Anesthesia was induce... 
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KW  - Anesthesia; Cardiovascular function; Horse; Medetomidine; Vatinoxan; CONSTANT RATE INFUSION; PERIPHERAL ALPHA-2-ADRENOCEPTOR ANTAGONIST; INTRAVENOUS DEXMEDETOMIDINE; ALPHA(2)-ADRENOCEPTOR ANTAGONIST; MK-467; DETOMIDINE; ANESTHESIA; ROMIFIDINE; HALOTHANE; XYLAZINE; 413 Veterinary science 
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ER  -