TY  -  
T1  - Efficacy of Sirolimus in Patients Requiring Tracheostomy for Life-Threatening Lymphatic Malformation of the Head and Neck : A Report From the European Reference Network 
SN  -  /  
UR  - http://hdl.handle.net/10138/335886 
T3  -  
A1  - Holm, Annegret; te Loo, Maroeska; Schultze Kool, Leo; Salminen, Päivi; Celis, Veronica; Baselga, Eulalia; Duignan, Sophie; Dvorakova, Veronika; Irvine, Alan D.; Boon, Laurence M.; Vikkula, Miikka; Ghaffarpour, Nader; Niemeyer, Charlotte M.; Rössler, Jochen; Kapp, Friedrich G. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Extensive lymphatic malformations (LMs) of the head and neck region may require tracheostomy to secure the airway. Treatment of these life-threatening LMs is usually multimodal and includes sclerotherapy and surgery, among others. Recently, systemic therapy with sirolimus has been introduced as an effective treatment for venous and lymphatic malformations; its efficacy and safety profile in patients with extensive LM requiring tracheostomy are, however, as yet not fully known. We performed a ret... 
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IS  -  
SP  -  
OP  -  
KW  - lymphatic malformation; rapamycin; sirolimus; tracheostoma; tracheostomy; vascular anomaly; 3123 Gynaecology and paediatrics 
N1  -   
PP  -  
ER  -