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T1  - Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases 
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UR  - http://hdl.handle.net/10138/333628 
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A1  - Bousquet, Jean; Le Moing, Vincent; Blain, Hubert; Czarlewski, Wienczyslawa; Zuberbier, Torsten; Torre, Raphael de la; Lozano, Nieves Pizarro; Reynes, Jacques; Bedbrook, Anna; Cristol, Jean-Paul; Cruz, Alvaro A.; Fiocchi, Alessandro; Haahtela, Tari; Iaccarino, Guido; Klimek, Ludger; Kuna, Piotr; Melén, Erik; Mullol, Joaquim; Samolinski, Boleslaw; Valiulis, Arunas; Anto, Josep M. 
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Y1  - 2021 
LA  - eng 
AB  - COVID-19 is described in a clinical case involving a patient who proposed the hypothesis that Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-interacting nutrients may help to prevent severe COVID-19 symptoms. Capsules of broccoli seeds containing glucoraphanin were being taken before the onset of SARS-CoV-2 infection and were continued daily for over a month after the first COVID-19 symptoms. They were found to reduce many of the symptoms rapidly and for a duration of 6-12 h by repeated dosi... 
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KW  - 3121 General medicine, internal medicine and other clinical medicine; COVID-19; Nrf2; broccoli; cough challenge; TRPA1; TRPV1; ACTIVATION; MECHANISM; SULFORAPHANE; STRATEGY; CHEMOPREVENTION; INDUCED CARDIOMYOPATHY; Cough challenge; RHINITIS; Broccoli; NRF2; RICH; COUGH 
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