TY  -  
T1  - Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor 
SN  -  /  
UR  - http://hdl.handle.net/10138/329179 
T3  -  
A1  - Li, Hao; Hohenstein, Peter; Kuure, Satu 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that could replenish functional homeostasis similarly to, e.g., skin or the hematopoietic system. Unlike a mature kidney, the embryonic kidney hosts at least three types of lineage-specific stem cells that give rise to (a) a ureter and collecting duct system, (b) nephrons, and (c) mesangial cells together with connective tissue of the stroma. Extensive interest has been raised towards these embryonic progenitor c... 
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KW  - kidney; organogenesis; pediatric cancer; stem cells; differentiation; self-renewal; NEPHRON PROGENITOR CELLS; DEVELOPING MOUSE KIDNEY; URETERAL BUD; BRANCHING MORPHOGENESIS; GENE-EXPRESSION; BETA-CATENIN; TRANSCRIPTION FACTOR; STROMAL PROGENITORS; NEUROTROPHIC FACTOR; SELF-RENEWAL; 1184 Genetics, developmental biology, physiology 
N1  -   
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ER  -