TY  -  
T1  - Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels 
SN  -  /  
UR  - http://hdl.handle.net/10138/300634 
T3  -  
A1  - Turunen, Pauli M.; Louhivuori, Lauri M.; Louhivuori, Verna; Kukkonen, Jyrki P.; Akerman, Karl E. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Cell-cell communication plays a central role in the guidance of migrating neuronal precursor cells during the development of the cerebral cortex. Endocannabinoids (eCBs) have previously been shown to be one of the central factors regulating neuronal migration. In this study the effects of eCBs on different parameters, expected to affect embryonic cortical neuronal motility have been analyzed in neurosphere-derived neuroblasts using time-lapse microscopy. Increased endogenous production of the en... 
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KW  - 2-AG; endocannabinoids; mGluR5; neuroblast; radial glia; TRPC3; NEURAL PROGENITOR CELLS; METABOTROPIC GLUTAMATE-RECEPTOR; ROSTRAL MIGRATORY STREAM; CENTRAL-NERVOUS-SYSTEM; SUBVENTRICULAR ZONE; MONOACYLGLYCEROL LIPASE; SYNAPTIC-TRANSMISSION; CANNABINOID RECEPTOR; MULTIPOLAR MIGRATION; NEUROTROPHIC FACTOR; 3112 Neurosciences; 3124 Neurology and psychiatry 
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ER  -