TY  -  
T1  - Endoplasmic Reticulum Stress Regulators : New Drug Targets for Parkinson's Disease 
SN  -  /  
UR  - http://hdl.handle.net/10138/335297 
T3  -  
A1  - Kovaleva, Vera; Saarma, Mart 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Parkinson's disease (PD) pathology involves progressive degeneration and death of vulnerable dopamine neurons in the substantia nigra. Extensive axonal arborization and distinct functions make this type of neurons particularly sensitive to homeostatic perturbations, such as protein misfolding and Ca2+ dysregulation. Endoplasmic reticulum (ER) is a cell compartment orchestrating protein synthesis and folding, as well as synthesis of lipids and maintenance of Ca2+ homeostasis in eukaryotic cells. ... 
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KW  - 3112 Neurosciences; 3124 Neurology and psychiatry; cerebral dopamine neurotrophic factor; endoplasmic reticulum stress; growth factors; mesencephalic astrocyte-derived neurotrophic factor; Parkinson's disease; unfolded protein response; ER-STRESS; NEUROTROPHIC FACTOR; DOWN-REGULATION; ALPHA-SYNUCLEIN; SUBSTANTIA-NIGRA; EXPERIMENTAL-MODELS; RAT MODEL; UNFOLDED-PROTEIN-RESPONSE; MIDBRAIN DOPAMINE NEURONS; CDNF PROTECTS 
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