TY  -  
T1  - Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke 
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UR  - http://hdl.handle.net/10138/306218 
T3  -  
A1  - CLOTBUST-ER Trial Investigators; Alexandrov, Andrei V.; Tsivgoulis, Georgios; Köhrmann, Martin; Soinne, Lauri; Schellinger, Peter D. 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recruitment among centers. Methods: We performed a post hoc analysis after excluding subjects that were recruited at centers reporting a decline in the balance of randomization between sonothrombolysis and concurrent endovascular trials. Results: From a total of 67... 
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KW  - endovascular; equipoise shift; intracranial hemorrhage; mechanical thrombectomy; outcome; recanalization; sonothrombolysis; stroke; ultrasound-enhanced thrombolysis; THROMBECTOMY; MANAGEMENT; ULTRASOUND; EFFICACY; SAFETY; CARE; 3112 Neurosciences; 3124 Neurology and psychiatry 
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ER  -