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T1  - Engineering the pH-Sensitivity of the Graphene and Carbon Nanotube Based Nanomedicines in Smart Cancer Therapy by Grafting Trimetyl Chitosan 
SN  -  /  
UR  - http://hdl.handle.net/10138/319242 
T3  -  
A1  - Khoshoei, Azadeh; Ghasemy, Ebrahim; Poustchi, Fatemeh; Shahbazi, Mohammad-Ali; Maleki, Reza 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - Purpose The aim of this study was to introduce a smart and responsive drug carrier for Doxorubicin (DOX) and Paclitaxel (PAX) for desirable therapeutic application. Method Loading and releasing of DOX and PAX from smart and pH-sensitive functionalized single-walled carbon nanotube (SWCNTs) and graphene carriers have been simulated by molecular dynamics. The influences of chitosan polymer on proposed carriers have been studied, and both carriers were functionalized with carboxyl groups to improve... 
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KW  - cancer therapy; graphene; molecular dynamic; nanomedicine; single walled carbon nanotube; DRUG-DELIVERY SYSTEMS; MOLECULAR SIMULATION; FORCE-FIELD; IN-VIVO; DOXORUBICIN; NANOPARTICLES; NANOMATERIALS; 317 Pharmacy; 318 Medical biotechnology; 221 Nano-technology 
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