TY  -  
T1  - Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML 
SN  -  /  
UR  - http://hdl.handle.net/10138/195929 
T3  -  
A1  - Malani, D.; Murumagi, A.; Yadav, B.; Kontro, M.; Eldfors, S.; Kumar, A.; Karjalainen, R.; Majumder, M. M.; Ojamies, P.; Pemovska, T.; Wennerberg, K.; Heckman, C.; Porkka, K.; Wolf, M.; Aittokallio, T.; Kallioniemi, O. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - We sought to identify drugs that could counteract cytarabine resistance in acute myeloid leukemia (AML) by generating eight resistant variants from MOLM-13 and SHI-1 AML cell lines by long-term drug treatment. These cells were compared with 66 ex vivo chemorefractory samples from cytarabine-treated AML patients. The models and patient cells were subjected to genomic and transcriptomic profiling and high-throughput testing with 250 emerging and clinical oncology compounds. Genomic profiling uncov... 
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IS  -  
SP  -  
OP  -  
KW  - ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; DRUG-RESISTANCE; CELL-LINES; IN-VITRO; DEOXYCYTIDINE KINASE; ONCOLOGY-GROUP; ARA-C; EXPRESSION; DEXAMETHASONE; 3122 Cancers 
N1  -   
PP  -  
ER  -