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T1  - Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes 
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UR  - http://hdl.handle.net/10138/327295 
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A1  - Sane, Famara; Bertin, Antoine; Sioofy-Khojine, Amir-Babak; Oikarinen, Sami; Alidjinou, Enagnon K.; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Knip, Mikael; Engelmann, Ilka; Hyöty, Heikki; Hober, Didier 
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Y1  - 2020 
LA  - eng 
AB  - Abstract Studies in prospective cohorts have suggested that enterovirus infections are associated with the appearance of islet autoantibodies that precede later appearance of type 1 diabetes (T1D). It was shown that in addition to an antibody-mediated anti-coxsackievirus (CV)-B neutralizing activity of serum from patients with T1D, there was also enhancing anti-CV-B activity in vitro. In this study the patterns of enhancing and neutralizing anti-CV activities were analyzed from consecutive serum... 
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KW  - 3121 General medicine, internal medicine and other clinical medicine; CV-A4; CV-B3; CV-B5; enhancing and neutralizing antibodies; enterovirus; IFN- α; in vitro; type 1 diabetes; ANTIBODIES; B4-INDUCED PRODUCTION; INDUCTION; IFN-alpha; BLOOD MONONUCLEAR-CELLS; ENTEROVIRUS; INTERFERON-ALPHA; B4; AUTOIMMUNITY; DEPENDENT ENHANCEMENT; IFN-ALPHA; 3111 Biomedicine 
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