TY  -  
T1  - Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms 
SN  -  /  
UR  - http://hdl.handle.net/10138/312866 
T3  -  
A1  - Ämmälä, Antti-Jussi; Urrila, Anna-Sofia; Lahtinen, Aleksandra; Santangeli, Olena; Hakkarainen, Antti; Kantojärvi, Katri; Castaneda, Anu E.; Lundbom, Nina; Marttunen, Mauri; Paunio, Tiina 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Objectives: This study aimed to test the hypothesis that sleep and depression have independent effects on brain development and plasticity in adolescents, and that these changes are reflected in changes in the epigenome. Methods: Participants were 17 medication-free adolescent boys (age 16.05 +/- 0.80 years, mean +/- standard deviation (SD); eight cases with depression and sleep symptoms, nine healthy controls). Sleep was assessed by polysomnography recordings and the Pediatric Daytime Sleepines... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ANXIETY; Adolescence; BRAIN-DEVELOPMENT; DAYTIME; DEPRIVATION; Depression; Epigenetics; INSOMNIA; INVENTORY; MEMORY; Mood; OUTPATIENTS; PLASTICITY; Polysomnography; QUALITY; Sleepiness; 3112 Neurosciences; 3124 Neurology and psychiatry 
N1  -   
PP  -  
ER  -