TY  -  
T1  - Esterase activity in porcine and albino rabbit ocular tissues 
SN  -  /  
UR  - http://hdl.handle.net/10138/244923 
T3  -  
A1  - Heikkinen, Emma M.; del Amo, Eva M.; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Corneal esterases are utilized in the activation of topically applied ester prodrugs. Esterases may also be involved in the metabolism of drugs in posterior eye tissues, but their physiological activity is unknown. Furthermore, extrapolation of the esterase activity from protein level to the tissues is missing. The aims of the current study were to determine esterase activities in porcine and albino rabbit ocular tissues, calculate the activities for whole tissues and compare esterase activity b... 
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KW  - Esterases; Ocular metabolism; Ocular ADME; Ocular prodrugs; Ocular drug bioavailability; PIGMENT EPITHELIAL-CELLS; SUBSTRATE-SPECIFICITY; DIPIVALYL EPINEPHRINE; DRUG; DISPOSITION; PRODRUG; HYDROLYSIS; METABOLISM; GANCICLOVIR; DIPIVEFRIN; 317 Pharmacy 
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