TY - T1 - Evaluating the Evidence behind the Novel Strategy of Early Combination from Vision to Implementation SN - / UR - http://hdl.handle.net/10138/326814 T3 - A1 - Paldanius, Päivi Maria A2 - PB - Y1 - 2020 LA - eng AB - Type 2 diabetes mellitus (T2DM) is a complex and progressive chronic disease characterised by elevating hyperglycaemia and as-sociated need to gradually intensify therapy in order to achieve and maintain glycaemic control. Treating hyperglycaemia with se-quential therapy is proposed to allow holistic assessment of the efficacy and risk-to-benefit ratio of each added component. How-ever, there is an array of evidence supporting the scientific rationale for using synergistic, earlier, modern drug ... VO - IS - SP - OP - KW - 3121 General medicine, internal medicine and other clinical medicine; BETA-CELL FUNCTION; TYPE-2 DIABETES-MELLITUS; METFORMIN-TREATED PATIENTS; INTENSIVE INSULIN THERAPY; BLOOD-GLUCOSE CONTROL; DRUG-NAIVE PATIENTS; INITIAL COMBINATION; CLINICAL INERTIA; GLYCEMIC CONTROL; BASAL INSULIN N1 - PP - ER -