TY  -  
T1  - Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action 
SN  -  /  
UR  - http://hdl.handle.net/10138/228730 
T3  -  
A1  - Voutilainen, Merja H.; De Lorenzo, Francesca; Stepanova, Polina; Bäck, Susanne; Pulkkila, Päivi; Pörsti, Eeva; Saarma, Mart; Männistö, Pekka T.; Tuominen, Raimo K. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Parkinson's disease (PD) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (DAergic) neurons of the substantia nigra (SN) and the accumulation of intracellular inclusions containing alpha-synuclein. Current therapies do not stop the progression of the disease, and the efficacy of these treatments wanes over time. Neurotrophic factors (NTFs) are naturally occurring proteins promoting the survival and differentiation of neurons and the maintenance of neuronal conta... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 317 Pharmacy; 3112 Neurosciences; 6-OHDA; additive effect; CDNF; ER stress; rat; ENDOPLASMIC-RETICULUM STRESS; NEUROTROPHIC FACTOR GDNF; MIDBRAIN DOPAMINE NEURONS; ADHESION MOLECULE NCAM; PARKINSONS-DISEASE; IN-VIVO; CDNF/MANF FAMILY; TYROSINE-HYDROXYLASE; SUBSTANTIA-NIGRA; GENE-THERAPY 
N1  -   
PP  -  
ER  -