TY  -  
T1  - Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers 
SN  -  /  
UR  - http://hdl.handle.net/10138/341880 
T3  -  
A1  - McDonald, Craig; Morrison, Vicky L.; McGloin, David; Fagerholm, Susanna Carola 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Integrins in effector T cells are crucial for cell adhesion and play a central role in cell-mediated immunity. Leukocyte adhesion deficiency (LAD) type III, a genetic condition that can cause death in early childhood, highlights the importance of integrin/kindlin interactions for immune system function. A TTT/AAA mutation in the cytoplasmic domain of the beta 2 integrin significantly reduces kindlin-3 binding to the beta 2 tail, abolishes leukocyte adhesion to intercellular adhesion molecule 1 (... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - LFA-1; kindlin-3; T cell; bond strength; ICAM-1; FUNCTION-ASSOCIATED ANTIGEN-1; T-CELL-ACTIVATION; INTEGRIN; LIGAND; ADHESION; 1182 Biochemistry, cell and molecular biology; 3121 General medicine, internal medicine and other clinical medicine 
N1  -   
PP  -  
ER  -