TY  -  
T1  - Excretion of the Polymyxin Derivative NAB739 in Murine Urine 
SN  -  /  
UR  - http://hdl.handle.net/10138/316320 
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A1  - Vaara, Martti; Vaara, Timo; Kuka, Janis; Sevostjanovs, Eduards; Grinberga, Solveiga; Dambrova, Maija; Liepinsh, Edgars 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Extremely multiresistant strains of Enterobacteriaceae are emerging and spreading at a worrisome pace. Polymyxins are used as the last-resort therapy against such strains, in spite of their nephrotoxicity. We have previously shown that novel polymyxin derivatives NAB739 and NAB815 are less nephrotoxic in cynomolgus monkeys than polymyxin B and are therapeutic in murine Escherichia coli pyelonephritis at doses only one-tenth of that needed for polymyxin B. Here we evaluated whether the increased ... 
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KW  - NAB739; polymyxin B; mouse pyelonephritis; extremely multiresistant strains of Enterobacteriaceae; GUIDELINES; 3111 Biomedicine; 3121 General medicine, internal medicine and other clinical medicine; 317 Pharmacy 
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