TY  -  
T1  - Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs) 
SN  -  /  
UR  - http://hdl.handle.net/10138/232545 
T3  -  
A1  - Kjällquist, Una; Erlandsson, Rikard; Tobin, Nicholas P; Alkodsi, Amjad; Ullah, Ikram; Stålhammar, Gustav; Karlsson, Eva; Hatschek, Thomas; Hartman, Johan; Linnarsson, Sten; Bergh, Jonas 
A2  -  
PB  - BioMed Central 
Y1  - 2018 
LA  -  
AB  - Abstract
              
                Background
                Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied. Many studies have revealed marked alterations of standard prognostic and predictive factors during tumor progression. Characterization of paired primary- and metastatic tissues should therefore be fundamental in order to u... 
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IS  -  
SP  -  
OP  -  
KW  - Breast cancer; Metastasis; Exome sequencing; Somatic mutations; AKAP; A-kinase anchoring proteins 
N1  -   
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ER  -