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T1  - Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster 
SN  -  /  
UR  - http://hdl.handle.net/10138/166129 
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A1  - Lindström, Riitta; Lindholm, Päivi; Kallijärvi, Jukka; Palgi, Mari; Saarma, Mart; Heino, Tapio I. 
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PB  -  
Y1  - 2016 
LA  - eng 
AB  - Disturbances in the homeostasis of endoplasmic reticulum (ER) referred to as ER stress is involved in a variety of human diseases. ER stress activates unfolded protein response (UPR), a cellular mechanism the purpose of which is to restore ER homeostasis. Previous studies show that Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is an important novel component in the regulation of UPR. In vertebrates, MANF is upregulated by ER stress and protects cells against ER stress-induced cell d... 
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KW  - ENDOPLASMIC-RETICULUM STRESS; NEUROTROPHIC FACTOR MANF; DOPAMINERGIC-NEURONS; GENE-EXPRESSION; CDNF PROTECTS; ERSE-II; CELLS; MODEL; BRAIN; YEAST; 1184 Genetics, developmental biology, physiology 
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ER  -