TY - T1 - Extended family history of type 1 diabetes inHLA-predisposed children with and without islet autoantibodies SN - / UR - http://hdl.handle.net/10138/325878 T3 - A1 - Kuusela, Salla; Keskinen, Päivi; Pokka, Tytti; Knip, Mikael; Ilonen, Jorma; Vähäsalo, Paula; Veijola, Riitta A2 - PB - Y1 - 2020 LA - eng AB - Objective The aim of this study was to explore the extended family history of type 1 diabetes in children at genetic risk and define the impact of a positive family history on the development of islet autoimmunity and type 1 diabetes. Methods The subjects were participants in The Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study and carried increased HLA-conferred risk for type 1 diabetes. The case children (N = 343) were positive for at least one islet autoantibody, and the control... VO - IS - SP - OP - KW - children; family history; genetic risk; HLA; islet autoimmunity; type 1 diabetes; BETA-CELL AUTOIMMUNITY; GENETIC SUSCEPTIBILITY; RISK; POPULATION; MELLITUS; MOTHERS; 3123 Gynaecology and paediatrics; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -