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T1  - FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth 
SN  -  /  
UR  - http://hdl.handle.net/10138/176712 
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A1  - Peippo, Minna; Gardberg, Maria; Lamminen, Tarja; Kaipio, Katja; Carpen, Olli; Heuser, Vanina D. 
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PB  -  
Y1  - 2017 
LA  - eng 
AB  - The functional properties of actin-regulating formin proteins are diverse and in many cases cell-type specific. FHOD1, a formin expressed predominantly in cells of mesenchymal lineage, bundles actin filaments and participates in maintenance of cell shape, migration and cellular protrusions. FHOD1 participates in cancer associated epithelial to mesenchymal transition (EMT) in oral squamous cell carcinoma and breast cancer. The role of FHOD1 in melanomas has not been characterized. Here, we show t... 
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KW  - Formin; FHOD1; Cytoskeleton; Actin; Melanoma; Tumorigenesis; SRE; MKL-1; MRTF-A; MAL; TAN LINE FORMATION; NUCLEAR-MOVEMENT; CELL-MIGRATION; ACTIN; ADHESION; EXPRESSION; PROTEIN; CANCER; REORGANIZATION; TRANSCRIPTION; 3111 Biomedicine; 3122 Cancers 
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