TY - T1 - Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing SN - / UR - http://hdl.handle.net/10138/304064 T3 - A1 - Quarto, Tiziana; Paparella, Isabella; De Tullio, Davide; Viscanti, Ciovanna; Fazio, Leonardo; Taurisano, Paolo; Romano, Raffaella; Rampino, Antonio; Masellis, Rita; Popolizio, Teresa; Selvaggi, Pierluigi; Pergola, Giulio; Bertolino, Alessandro; Blasi, Giuseppe A2 - PB - Y1 - 2018 LA - eng AB - The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal functional integration between areas key for emotion processing, such as the amygdala and the lateral prefrontal cortex (LPFC). Indeed, investigation of these mechanisms is also complicated by emotion processing comprising different subcomponents and by disease-associated state variables. Here, our aim was to investigate the relationship between risk for SCZ and effective ... VO - IS - SP - OP - KW - endophenotype; DRD2 rs2514218; dynamic causal model; implicit emotion processing; explicit emotion processing; DIFFERENTIAL NEURAL RESPONSE; FACIAL EXPRESSIONS; SYNAPTIC PLASTICITY; COGNITIVE DYSMETRIA; UNAFFECTED SIBLINGS; BRAIN ACTIVATION; NEGATIVE EMOTION; FEAR; PSYCHOSIS; CORTEX; 3124 Neurology and psychiatry; 515 Psychology; 3111 Biomedicine N1 - PP - ER -