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T1  - Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging 
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UR  - http://hdl.handle.net/10138/326618 
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A1  - Mihaylova, Maria M.; Cheng, Chia-Wei; Cao, Amanda Q.; Tripathi, Surya; Mana, Miyeko D.; Bauer-Rowe, Khristian E.; Abu-Remaileh, Monther; Clavain, Laura; Erdemir, Aysegul; Lewis, Caroline A.; Freinkman, Elizaveta; Dickey, Audrey S.; La Spada, Albert R.; Huang, Yanmei; Bell, George W.; Deshpande, Vikram; Carmeliet, Peter; Katajisto, Pekka; Sabatini, David M.; Yilmaz, Ömer H. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FA... 
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KW  - 1184 Genetics, developmental biology, physiology; 1182 Biochemistry, cell and molecular biology; stem cells; intestinal stem cells; fasting; aging; metabolism; intestine; fatty acid oxidation; mitochondrial metabolism; LIFE-SPAN; REGENERATION; TISSUE HOMEOSTASIS; CANCER; IN-VITRO; MTORC1; METABOLISM; PPAR-DELTA; LGR5; CALORIE RESTRICTION 
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