TY - T1 - Fertility preservation in boys : recent developments and new insights SN - / UR - http://hdl.handle.net/10138/333399 T3 - A1 - Goossens, E.; Jahnukainen, K.; Mitchell, R. T.; van Pelt, A. M. M.; Pennings, G.; Rives, N.; Poels, J.; Wyns, C.; Lane, S.; Rodriguez-Wallberg, K. A.; Rives, A.; Valli-Pulaski, H.; Steimer, S.; Kliesch, S.; Braye, A.; Andres, M. M.; Medrano, J.; Ramos, L.; Kristensen, S. G.; Andersen, C. Y.; Bjarnason, R.; Orwig, K. E.; Neuhaus, N.; Stukenborg, J. B. A2 - PB - Y1 - 2020 LA - eng AB - BACKGROUND: Infertility is an important side effect of treatments used for cancer and other non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (SSCs) and/or altered functionality of testicular somatic cells (e.g. Sertoli cells, Leydig cells). Whereas sperm cryopreservation is the first-line procedure to preserve fertility in post-pubertal males, this option does not exist for prepubertal boys. For patients unable to produce sperm and at high risk of losin... VO - IS - SP - OP - KW - cryopreservation; in vitro spermatogenesis; fertility preservation; fertility restoration; prepubertal boys; spermatogonial stem cell; testicular tissue freezing; testis; transplantation; SPERMATOGONIAL STEM-CELLS; TESTICULAR TISSUE CRYOPRESERVATION; ENDOTHELIAL GROWTH-FACTOR; LONG-TERM PROPAGATION; PRE-PUBERTAL BOYS; IN-VITRO; GONADAL-FUNCTION; TESTIS TISSUE; GERM-CELLS; SPERM CRYOPRESERVATION; 3123 Gynaecology and paediatrics N1 - PP - ER -