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T1  - Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells 
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UR  - http://hdl.handle.net/10138/320831 
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A1  - Helle, Emmi; Ampuja, Minna; Antola, Laura; Kivelä, Riikka 
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Y1  - 2020 
LA  - eng 
AB  - The vascular system is essential for the development and function of all organs and tissues in our body. The molecular signature and phenotype of endothelial cells (EC) are greatly affected by blood flow-induced shear stress, which is a vital component of vascular development and homeostasis. Recent advances in differentiation of ECs from human induced pluripotent stem cells (hiPSC) have enabled development of in vitro experimental models of the vasculature containing cells from healthy individu... 
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KW  - 3112 Neurosciences; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology; endothelial cells; induced pluripotent stem cells; shear stress; flow; single-cell RNA sequencing; RNA sequencing; PLACENTAL GROWTH-FACTOR; EXPRESSION; GENERATION; IDENTIFICATION; ANGIOGENESIS; COMPONENT; PERICYTES; MICE; GENE; SET 
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