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T1  - Forebrain-independent generation of hyperthermic convulsions in infant rats 
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UR  - http://hdl.handle.net/10138/177886 
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A1  - Pospelov, Alexey S.; Yukin, Alexey Y.; Blumberg, Mark S.; Puskarjov, Martin; Kaila, Kai 
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Y1  - 2016 
LA  - eng 
AB  - Febrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13-day-old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic-clonic convulsions induced by hyperthermia or kainate. Compared with sham-operated littermate controls, latency to... 
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KW  - Brainstem; Precollicular transection; Febrile seizures; Diazepam; Kainic acid; EXPERIMENTAL FEBRILE SEIZURES; BRAIN-STEM; RESPIRATORY ALKALOSIS; ACTIVATION; CHILDREN; SLEEP; 3112 Neurosciences 
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