TY - T1 - Forebrain-independent generation of hyperthermic convulsions in infant rats SN - / UR - http://hdl.handle.net/10138/177886 T3 - A1 - Pospelov, Alexey S.; Yukin, Alexey Y.; Blumberg, Mark S.; Puskarjov, Martin; Kaila, Kai A2 - PB - Y1 - 2016 LA - eng AB - Febrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13-day-old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic-clonic convulsions induced by hyperthermia or kainate. Compared with sham-operated littermate controls, latency to... VO - IS - SP - OP - KW - Brainstem; Precollicular transection; Febrile seizures; Diazepam; Kainic acid; EXPERIMENTAL FEBRILE SEIZURES; BRAIN-STEM; RESPIRATORY ALKALOSIS; ACTIVATION; CHILDREN; SLEEP; 3112 Neurosciences N1 - PP - ER -