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T1  - Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents : A Proton Magnetic Resonance Spectroscopy Study 
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UR  - http://hdl.handle.net/10138/310859 
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A1  - Urrila, Anna S.; Hakkarainen, Antti; Castaneda, Anu; Paunio, Tiina; Marttunen, Mauri; Lundbom, Nina 
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Y1  - 2017 
LA  - eng 
AB  - Aim: This study used proton magnetic resonance spectroscopy (H-1 MRS) to evaluate the neurochemistry of the frontal cortex in adolescents with symptoms of sleep and depression. Methods: Nineteen non-medicated adolescent boys (mean age 16.0 years; 9 clinical cases with depression/sleep symptoms and 10 healthy controls) underwent H-1 MRS at 3 T. MR spectra were acquired from the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex, and frontal white matter. Concentrations of N-acety... 
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KW  - Adolescent; Depression; Frontal cortex; Magnetic resonance spectroscopy; Magnetic resonance imaging; Myo-inositol; Polysomnography; Sleep; Sleepiness; Youth; ANTERIOR CINGULATE CORTEX; DORSOLATERAL PREFRONTAL CORTEX; RANDOMIZED EFFECTIVENESS TRIAL; PEDIATRIC MAJOR DEPRESSION; ALZHEIMER-DISEASE; PSYCHIATRIC-DISORDERS; DAYTIME SLEEPINESS; TREATMENT RESPONSE; BIPOLAR DISORDER; MR SPECTROSCOPY; 3112 Neurosciences; 3124 Neurology and psychiatry 
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