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T1  - Functional genomics of ORP2 or protrudin knockdown in human umbilical vein endothelial cells 
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UR  - URN:NBN:fi:hulib-201910303803; http://hdl.handle.net/10138/306553 
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A1  - Taskinen, Juuso 
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PB  - Helsingin yliopisto 
Y1  - 2019 
LA  - eng 
AB  - Human umbilical vein endothelial cells are responsible for maintaining and forming new vessels from existing ones, in a biological process called sprouting angiogenesis.  Sprouting angiogenesis is a crucial mechanism for the resolution of hypoxia and normal development of tissues. It also plays a key role in internal plague hemorrhages, which can lead to embolisms and other cardiovascular complications. Angiogenesis is also crucial for cancer development. Sprouting angiogenesis is initiated by h... 
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KW  - angiogeneesi; endoteelisolu; geenien ilmentyminen; ORP2; protrudiini; RNA-sekvensointi; kalvokontaktiproteiini; funktionaalinen genetiikka; RNA-sequencing; ORP2; protrudin; membrane contacts site; angiogenesis; endothelial cell; gene expression; functional genomics; Molekulaaristen ja analyyttisten biotieteiden opintosuunta; Molecular and Analytical Health Biosciences; Molekylärä och analytiska biovetenskaper; Genetiikan ja molekulaaristen biotieteiden maisteriohjelma; Master's Programme in Genetics and Molecular Biosciences; Magisterprogrammet i genetik och molekylära biovetenskaper 
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