TY  -  
T1  - GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons 
SN  -  /  
UR  - http://hdl.handle.net/10138/324699 
T3  -  
A1  - Chmielarz, Piotr; Er, Safak; Konovalova, Julia; Bandres, Laura; Hlushchuk, Irena; Albert, Katrina; Panhelainen, Anne; Luk, Kelvin; Airavaara, Mikko; Domanskyi, Andrii 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Background Parkinson's disease (PD) is associated with proteostasis disturbances and accumulation of misfolded alpha-synuclein (alpha-syn), a cytosolic protein present in high concentrations at pre-synaptic neuronal terminals. It is a primary constituent of intracellular protein aggregates known as Lewy neurites or Lewy bodies. Progression of Lewy pathology caused by the prion-like self-templating properties of misfolded alpha-syn is a characteristic feature in the brains of PD patients. Glial c... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - GDNF; Parkinson's disease; alpha-synuclein; dopamine neuron; misfolded protein accumulation; ALPHA-SYNUCLEIN FIBRILS; PARKINSONS-DISEASE; C-ABL; TYROSINE KINASE; LIPID RAFTS; RET; RECEPTOR; NEURODEGENERATION; SRC; 3112 Neurosciences 
N1  -   
PP  -  
ER  -