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T1  - GNEN-1 : a spontaneously immortalized cell line from gastric neuroendocrine neoplasia 
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UR  - http://hdl.handle.net/10138/336788 
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A1  - Fagerstedt, Klaus W.; Böhling, Tom; Sihto, Harri; Salonen, Tarja; Zhao, Fang; Kero, Mia; Andersson, Leif C.; Arola, Johanna 
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Y1  - 2021 
LA  - eng 
AB  - Mixed neuroendocrine-non-neuroendocrine neoplasms (MINEN) are rare tumors that consist of at least 30% of both neuroendocrine and non-neuroendocrine components. The data concerning the pathogenesis of MINEN suggest a monoclonal origin. We describe a spontaneously immortalized cell line derived from gastric MINEN called GNEN-1. Primary tumor consisted of components of high-grade neuroendocrine carcinoma and adenocarcinoma. The GNEN-1 cell line was initiated from metastatic tumor cells of peritone... 
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KW  - Cell line; Gastric cancer; MINEN; Neuroendocrine; STC1; chromogranin A; cisplatin; cytokeratin; eosin; etoposide; glutaraldehyde; hematoxylin; hypocalcin; osmium tetraoxide; paraformaldehyde; synaptophysin; adenocarcinoma; Article; axon hillock; cancer prognosis; case report; cholecystectomy; clinical article; comparative genomic hybridization; computer assisted tomography; controlled study; gastroscopy; gene expression; genome analysis; histology; histopathology; human; human cell; human tissue; immunohistochemistry; karyotype; karyotyping; liver metastasis; neuroendocrine carcinoma; phenotype; real time polymerase chain reaction; RNA extraction; spontaneously immortalized cell line; stomach carcinoma; transmission electron microscopy; trisomy 7; trisomy 8; neuroendocrine; MIXED ADENONEUROENDOCRINE CARCINOMA; CANCER; ISL1; CYTOGENETIC CHARACTERIZATION; TUMORS; cell line; gastric cancer; REG-IV; EXPRESSION; 3111 Biomedicine 
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