TY  -  
T1  - Ga-68-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism 
SN  -  /  
UR  - http://hdl.handle.net/10138/342040 
T3  -  
A1  - Boss, Marti; Rottenburger, Christof; Brenner, Winfried; Blankenstein, Oliver; Prasad, Vikas; Prasad, Sonal; de Coppi, Paolo; Kuhnen, Peter; Buitinga, Mijke; Nuutila, Pirjo; Otonkoski, Timo; Hussain, Khalid; Brom, Maarten; Eek, Annemarie; Bomanji, Jamshed; Shah, Pratik; Gotthardt, Martin 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds the glucagonlike peptide 1 receptor on pancreatic beta-cells. In this study, we compared the performance of F-18-DOPA PET/CT, the current standard imaging method for CHI, and PET/CT with the new tracer Ga-68-NODAGA-exendin-4 in the preoperative detection of focal CHI. Methods: Nineteen CHI patients underwent both F-18-DOPA PET/CT a... 
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KW  - congenital hyperinsulinism; focal CHI; diagnostic imaging; Ga-68-NODAGA-exendin-4 PET/CT; F-18-DOPA PET/CT; 11P15 IMPRINTED GENES; DIAGNOSIS; LOCALIZATION; MANAGEMENT; MUTATION; CHILDREN; INFANCY; DIFFUSE; FORMS; 3126 Surgery, anesthesiology, intensive care, radiology 
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